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ZECUITY® (sumatriptan iontophoretic transdermal system) may cause serious side effects including heart
attack or other heart problems, allergic contact dermatitis, changes in color or sensation in your fingers and
toes, stomach and intestinal problems, problems with blood circulation to your legs and feet, medication
overuse headaches, serotonin syndrome, increases in blood pressure, serious allergic reactions, or seizures.

Read More Important Safety Information >>



You may be looking for a
non-oral treatment option.2

ZECUITY delivers migraine medicine through the skin.1 Get Connected and be among the first to find out more about ZECUITY and when it will be available to you.

ZECUITY is a prescription medicine used for the acute treatment of migraine headaches with or without aura in adults. ZECUITY comes in an iontophoretic transdermal system (TDS) that uses a mild electrical current to deliver the medicine sumatriptan through your skin.

ZECUITY is used for people who have been told by a healthcare provider that they have migraine headaches. ZECUITY is not used to prevent or decrease the number of migraine headaches you have.


What important information should I know about ZECUITY?
ZECUITY can cause serious side effects, including: heart attack and other heart problems, which may lead to death.

Stop using ZECUITY and get emergency medical help right away if you have any of the following symptoms of a heart attack:

  • chest pain or chest discomfort that feels like an uncomfortable heavy pressure, squeezing, fullness, or pain that lasts for more than a few minutes, or that goes away and comes back
  • pain or discomfort in your arms, back, neck, jaw, or stomach
  • shortness of breath
  • breaking out in a cold sweat
  • nausea or vomiting
  • feeling lightheaded

ZECUITY is not for people with risk factors for heart disease unless a heart exam is done and shows no problem.

Who should not use ZECUITY?

Do not use ZECUITY if you have:

  • heart problems or a history of heart problems
  • had a stroke, transient ischemic attacks (TIAs), or problems with your blood circulation
  • narrowing of blood vessels to your legs, arms, stomach, or kidney (peripheral vascular disease)
  • uncontrolled high blood pressure
  • hemiplegic migraines or basilar migraines. If you are not sure if you have these, ask your healthcare provider
  • taken any of the following medicines in the last 24 hours: almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan and
    naproxen, ergotamines, or dihydroergotamine. Ask your healthcare provider if you are not sure if your medicine is listed above.
  • severe liver problems
  • an allergy to sumatriptan, the medicine in ZECUITY, or any of the components in ZECUITY TDS.

What should I avoid while using ZECUITY?

  • Do not bathe, shower, or swim while wearing ZECUITY.
  • ZECUITY can cause dizziness, weakness, or drowsiness. If you have these symptoms, do not drive a car, use machinery, or do anything where you need to be alert.
  • You should remove ZECUITY before you have a Magnetic Resonance Imaging (MRI) procedure.

What are possible side effects of ZECUITY?

ZECUITY may cause serious side effects including:

  • heart attack and other heart problems (see above)
  • injury during a Magnetic Resonance Imaging (MRI). The ZECUITY TDS contains metal parts and must be removed before an MRI.
  • allergic contact dermatitis (ACD). Some people have had a serious skin reaction called allergic contact dermatitis (ACD) where ZECUITY is applied. Symptoms of ACD include: skin itching, redness, irritation, blistering, peeling, or tenderness.
    You should stop using ZECUITY and call your healthcare provider if you have any of the symptoms of ACD. If you have or have had ACD while using ZECUITY and need to take sumatriptan by mouth or injection, your first dose of sumatriptan should be given in your healthcare provider’s office or in another medical setting.
  • changes in color or sensation in your fingers and toes (Raynaud’s syndrome)
  • stomach and intestinal problems (gastrointestinal and colonic ischemic events)
  • problems with blood circulation to your legs and feet (peripheral vascular ischemia)
  • medication overuse headaches. Some people who use too many ZECUITY may have worse headaches (medication overuse headache).
  • serotonin syndrome. Serotonin syndrome is a rare but serious problem that can happen in people using ZECUITY, especially if ZECUITY is used with anti-depressant medicines called SSRIs or SNRIs. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.
    Call your healthcare provider right away if you have any of the following symptoms of serotonin syndrome: mental changes such as seeing things that are not there (hallucinations), agitation, or coma; fast heartbeat; changes in blood pressure; high body temperature; tight muscles; trouble walking; or nausea, vomiting, or diarrhea.
  • increases in blood pressure. You should not use ZECUITY if you have uncontrolled high blood pressure.
  • serious allergic reactions. Get medical help right away if you have any of these symptoms of a serious allergic reaction: swelling of your face, lips, mouth, or tongue; trouble breathing; wheezing; severe itching; skin rash, redness, or swelling; dizziness or fainting; fast heartbeat or pounding in your chest (tachycardia); or sweating.
  • seizures. Seizures have happened in people taking sumatriptan who have never had seizures before. Talk with your healthcare provider about your chance of having seizures while you take ZECUITY.

The most common side effects of ZECUITY include pain, tingling, itching, warmth, discomfort or a change in the skin color at the application site of ZECUITY.

Most people have some skin redness after removal of ZECUITY. This redness will usually go away in 24 hours. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of ZECUITY. For more information, ask your healthcare provider or pharmacist.

Please read the Patient Information and Instructions for Use in the Full Prescribing Information for ZECUITY.

References: 1. ZECUITY [prescribing information]. North Wales, PA: Teva Pharmaceuticals USA, Inc; 2014. 2. Láinez MJ, García-Casado A, Gascón F. Optimal management of severe nausea and vomiting in migraine: improving patient outcomes. Patient Relat Outcome Meas. 2013;4:61-73.